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In the olden days you could move the WSUS content to a different partition using the SBS console, but you may also want to move the database itself (which can become quite large to say the least), and the instructions are still relevant today: Move WSUS Content and Database.
Reduce size of large WinSxS folder
A (Windows 2016) server with a perfectly reasonable 200GB Windows partition was reporting as low on free disk space....